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. 2017 Jan 18;7:40681. doi: 10.1038/srep40681

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Copyright © 2017, The Author(s)

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Three dimensional reconstruction images from micro-CT analysis (a). IFN-γ decreased the BMD, BV/TV, Tb. Th and the Tb. N parameters, but increased the Tb. Sp parameter (b–f). TNF-κB inhibitor (PDTC) and MAPK inhibitor (SB203580) reversed the effects induced by IFN-γ in DPSCs in vivo. (BMD: bone mineral density; BV/TV: bone volume/total volume; Tb. Th: trabecular thickness; Tb. N: trabecular number; Tb. Sp: trabecular separation). *P < 0.05 when compared with the control group. ^#P < 0.05 when compared with the IFN-γ group. (n = 4 for each group).