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. 2017 Jan 18;7:40681. doi: 10.1038/srep40681

Figure 7. Histological analyses of dental pulp stem cells (DPSCs) seeded on NF-gelatin scaffolds after 4 weeks of ectopic in vivo implantation in immunodeficient mice.

Figure 7

Histology of control cell-scaffold constructs (a,e,i), IFN-γ treated cell-scaffold constructs (b,f,j), cell-scaffold constructs co-stimulated with IFN-γ and PDTC (c,g,k) and cell-scaffold constructs co-stimulated with IFN-γ and SB203580 (d,h,l). H&E staining (a–d), Masson’s trichrome staining (e–h), Van Gieson staining (i–l). Scale bars = 100 μm. Black arrows: the newly formed ECM-like architecture. Red arrows: mineralized tissue consisting of newly formed dentin-like matrix. Quantitative analyses of the newly formed dentin-like matrix areas quantified using Image-Pro Plus 6.0 software (m). *P < 0.05 when compared with the control group. #P < 0.05 when compared with the IFN-γ group. (n = 4 for each group).