Figure 1. Conformational dynamics of Aβ42 LFAO dodecamers.
LFAOs have been previously shown to undergo a concentration-dependent transition between discrete 12mers (56 kDa, single arrow) to disperse 12-24mers (110 kDa, double arrow) with a dissociation constant (Kd) of 0.1 μM. Reproduced with permission14.