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. 2017 Jan 18;7:40787. doi: 10.1038/srep40787

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Copyright © 2017, The Author(s)

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At low concentrations (sub-μM) LFAOs are primarily 12mers (replicons) and undergo replication to form 12-24mers (amplification phase). It is important to bear in mind that LFAOs are not discrete oligomers but have some degree of heterogeneity and behave like a ‘cloud’. The schematic is only a cartoon representation of the oligomers and does not represent the actual structure. In a rate-limiting step, 12-24mers form LFAO propagons (48-96 mers), which undergo typical prion propagation to form large aggregates with unique morphology. iLFAO fragments can be generated from LFAO-seeded aggregates via sonication, which undergo both monomer and oligomer (pLFAO) elongation.