Table 4.
Regulatory genes regulated by TGFβ signaling.
| Hedgehog and Patched | ||||
| Gene | Type of gene | Fold regulation | p value | Mountain |
| grd-2 | groundhog | -2.4 | 0.0005 | 14 |
| grd-7 | ground domain only | 3.8 | 0.0003 | 13 |
| grd-6 | ground domain only | -3.1 | 0.0002 | 16 |
| grd-14 | ground domain only | -8.9 | 0.0002 | 16 |
| wrt-7 | warthog | 6.7 | 0.01 | 17 |
| wrt-1 | warthog | -6.8 | 0.0001 | 14 |
| wrt-4 | warthog | -2.9 | 0.0003 | 14 |
| wrt-6 | warthog | -2.7 | 0.0005 | 14 |
| wrt-8 | warthog | -3.8 | 0.0005 | 14 |
| wrt-2 | wart domain only | -1.8 | 0.008 | 14 |
| C56A3.1 | ground-like | 4.8 | 0.0001 | 17 |
| K03B8.7 | ground-like | 18.9 | 0.0003 | 17 |
| ZC487.4 | ground-like | 3.4 | 0.009 | 17 |
| C24G6.7 | ground-like | -3.6 | 0.0006 | 14 |
| F42C5.7 | ground-like | -2.4 | 0.0007 | 1 |
| T02E9.2 | ground-like | -7.7 | 0.0001 | 14 |
| Y75B8A.20 | ground-like | -13.3 | 0.0001 | 14 |
| ZC168.5 | ground-like | -4.6 | 0.0001 | 16 |
| ptc-3 | patched | -2.1 | 0.0001 | 1 |
| ptr-6 | patched related | -2.3 | 0.0008 | 14 |
| ptr-11 | patched related | -2.6 | 0.0002 | 1 |
| ptr-16 | patched related | -2.7 | 0.01 | 14 |
| ptr-18 | patched related | -3.3 | 0.0002 | 16 |
| ptr-23 | patched related | -2.5 | 0.0003 | 6 |
| npc-2 | patched family | -2.5 | 0.0004 | 16 |
| Dauer growth arrest | ||||
| Gene | Type of gene | Fold regulation | p value | |
| dbl-1 | TGFβ ligand, regulates growth and body size | -2.4 | 0.001 | |
| cdk-4 | cyclin dependent kinase | -1.9 | 0.006 | |
| nhr-73 | member of a family of NHR genes expressed exclusively in lateral hypodermis (seam cells) | -4.4 | 0.00002 | |
| nhr-74 | member of a family of NHR genes expressed exclusively in lateral hypodermis (seam cells) | -5.5 | 0.00005 | |
| nhr-25 | similar to NHR in Drosophila ecdysone regulatory cascade, required for embryogenesis and molting | -2.4 | 0.001 | |
| G-protein-coupled receptors and olfaction | ||||
| gene | type of gene | fold regulation | p value | |
| srh-75 | chemoreceptor | 2.6 | 0.007 | |
| srh-195 | chemoreceptor | 2.6 | 0.0009 | |
| srj-32 | chemoreceptor | 5.8 | 0.002 | |
| sru-21 | chemoreceptor | 6.3 | 0.0007 | |
| 32 genes | chemoreceptor | 1.8 to 6.3 | 0.05 or less | |
| 15 genes | GPCR, not chemoreceptor type | 1.8 to 3.6 | 0.05 or less | |
| C30F12.6 | thyrotropin-releasing hormone receptor ortholog | 1.8 | 0.002 | |
| npp-10 | GPCR, nucleoporin | -1.8 | 0.001 | |
| 6 genes | chemoreceptors | -1.8 to -3.8 | 0.05 or less | |
| gpa-10 | G protein alpha subunit | 2.0 | 0.003 | |
| Y71H2B.7 | G protein alpha subunit | -1.8 | 0.0001 | |
| F45B8.2 | regulator of G-protein signaling domain | 2.4 | 0.03 | |
| gcy-22 | receptor guanylate cyclase | 2.7 | 0.03 | |
| gcy-31 | soluble guanylate cyclase | 1.8 | 0.01 | |
| gcy-34 | soluble guanylate cyclase | 1.8 | 0.03 | |
| tax-2 | cyclic nucleotide gated channel beta subunit | 3.0 | 0.02 | |
| lim-6 | homeobox protein, functions to allow chemosensory neurons to sense different molecules | 2.0 | 0.003 | |
| Notch pathway | ||||
| gene | type of gene | fold regulation | p value | |
| W02C12.1 | notch family | 3.9 | 0.0007 | |
| F47C12.1 | notch family | 7.4 | 0.0003 | |
| apx-1 | ligand for GLP-1, notch receptor | 1.8 | 0.02 | |
| R03D7.5 | shaggy/GSK3 kinase | 2.2 | 0.002 | |
| lag-1 | ortholog of CBF1 and Suppressor of Hairless | 1.6 | 0.0003 | |
| Transcriptional regulators | ||||
| gene | type of gene | fold regulation | p value | |
| lin-28 | cold-shock domain | 1.8 | 0.0001 | |
| lin-29 | zinc finger transcription factor | -1.9 | 0.0002 | |
A complete list of significantly regulated regulatory genes can be found in additional file 4: Table S4.