Table 1. Pearson correlation and multiple regression analysis for SNRPN, PEG10 and MEST in all five placental villous groups.

		Pearson Correlation analysis: r			Multiple regression analysis with mRNA expression as dependent variable: r2 (SEM)#
Gene		H3K9me3	H3K27me3	mRNA vs DNA methylation
SNRPN	mRNA	0.12	−0.89*	−0.93*	0.99* (0.00029)
	DNA methylation	−0.2	0.75
PEG10	mRNA	−0.73	−0.31	−0.97**	0.99*(0.0042)
	DNA methylation	0.54	0.1
MEST	mRNA	−0.87	−0.88*	−0.75	0.84 (0.0047)
	DNA methylation	0.88*	0.63

R = Pearson coefficient, r² = regression determination coefficient, SEM = standard error of measurement, UD = undetermined due to unmethylated gene DMR/promoter. ^#Equation for Prediction for each gene was “mRNA expression = β1H3K9me3 + β2H3K27me3 + β3DNA methylation + α”, where β1, β2, β3 are regression coefficients and α is intercept of test. *p < 0.05 and **p < 0.01.