FIGURE 10.

Calpain overexpression or inhibition of PTP1B accelerates wound healing. Calpain activation or PTP1B inhibition promotes diabetic wound healing. A, representative images of wound areas on day 0, 6, and 12 of STZ-induced diabetic mice. STZ-injected mice were treated with VEGF alone or in combination with human calpain plasmids or PTP1B inhibitor. B, wound areas on day 12 were analyzed and normalized to initial wound area on day 0. n = 4–6. *, p < 0.05; **, p < 0.01 as indicated. CAPN: overexpression with human calpain 1 and calpain 2 plasmids (Addgene plasmids #60941 and #60942). PTP1Bi: PTP1B inhibitor (Calbiochem).