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. 2016 Nov 21;292(2):407–416. doi: 10.1074/jbc.M116.766832

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FIGURE 11. — Calpain/PTP1B/VEGFR2-feedback axis in VEGF-induced angiogenesis: Utilization for improving diabetic wound healing. Under normal conditions, VEGF activates calpain through VEGFR2, which is negatively regulated by calpain/PTP1B feedback axis. Genetic or pharmacological blockade of the feedback augments VEGF-induced downstream signaling, angiogenesis, and diabetic wound healing. Topical inhibition of PTP1B or activation of calpain may serve as novel therapeutics for impaired diabetic wound healing.