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Activation of Gi2 and Goa by CCR2 and CCR5 upon stimulation by J113863 or UCB35625. Real-time measurement of BRET signal in HEK293T cells coexpressing CCR2 (A and B) or CCR5 (C and D) and G protein biosensors and stimulated with increasing concentration of CCL2 (▴), CCL4 (■), UCB35625 (●), or J113863 (○). Results are expressed as the difference in BRET signal measured in the presence and absence of stimulation. Data represent the mean ± S.E. of three independent experiments.
