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F3.33H substitution does not impact significantly the binding of UCB35625 and J113863 to CCR5. Competition binding assays performed on cells expressing wild type CCR5 (A) or CCR5F3.33H (B) incubated with 0.1 nm 125I-CCL4 as tracer and increasing concentrations of unlabeled CCL4 (■), UCB35625 (●), or J113863 (○) as competitors. The data were normalized for nonspecific binding (0%) in the presence of 300 nm of unlabeled chemokine and specific binding in the absence of competitor (100%).
