TABLE 1.
Binding and signaling parameters of J113863 and UCB35625
Binding and functional parameters were measured on cells expressing CCR2 or CCR5. The pIC50 and pEC50 and Emax values were obtained from experiments as displayed in Figs. 1 and 2. Values represent the mean ± S.E. of at least three independent experiments. NT, not tested; ND, not determined.
| Ligands | CCR2 |
CCR5 |
||||
|---|---|---|---|---|---|---|
|
125I-CCL2 |
Ca2+ |
125I-CCL4 |
Ca2+ |
|||
| pIC50 | pEC50 | Emax | pIC50 | pEC50 | Emax | |
| CCL2 | 9.7 ± 0.1 | 9.4 ± 0.1 | 99 ± 5 | NT | NT | NT |
| CCL4 | NT | NT | NT | 9,4 ± 0,1 | 8.2 ± 0.1 | 67 ± 5 |
| J113863 | 5.5 ± 0.1 | 6.4 ± 0.1 | 101 ± 4 | 5,9 ± 0.1 | 5.8 ± 0.1 | 16 ± 1 |
| UCB35625 | 5.4 ± 0.1 | ND | ND | 5,6 ± 1,3 | ND | ND |