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. 2016 Nov 28;292(2):575–584. doi: 10.1074/jbc.M116.757559

TABLE 1.

Binding and signaling parameters of J113863 and UCB35625

Binding and functional parameters were measured on cells expressing CCR2 or CCR5. The pIC50 and pEC50 and Emax values were obtained from experiments as displayed in Figs. 1 and 2. Values represent the mean ± S.E. of at least three independent experiments. NT, not tested; ND, not determined.

Ligands CCR2
CCR5
125I-CCL2
Ca2+
125I-CCL4
Ca2+
pIC50 pEC50 Emax pIC50 pEC50 Emax
CCL2 9.7 ± 0.1 9.4 ± 0.1 99 ± 5 NT NT NT
CCL4 NT NT NT 9,4 ± 0,1 8.2 ± 0.1 67 ± 5
J113863 5.5 ± 0.1 6.4 ± 0.1 101 ± 4 5,9 ± 0.1 5.8 ± 0.1 16 ± 1
UCB35625 5.4 ± 0.1 ND ND 5,6 ± 1,3 ND ND