TABLE 2.
Ligands | CCR2 |
CCR5 |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gαi2 |
Gαoa |
β-Arr2 |
Gαi2 |
Gαoa |
β-Arr2 |
|||||||
pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | |
CCL2 | 8.45 ± 0.13 | 0.17 ± 0.01 | 8.61 ± 0.22 | 0.05 ± 0.01 | 8.50 ± 0.06 | 0.14 ± 0.06 | NT | NT | NT | NT | NT | NT |
CCL4 | NT | NT | NT | NT | NT | NT | 8.46 ± 0.29 | 0.08 ± 0.01 | 8.55 ± 0.20 | 0.05 ± 0.01 | 7.85 ± 0.11 | 0.10 ± 0.04 |
J113863 | 5.68 ± 0.27 | 0.14 ± 0.02 | 5.17 ± 0.33 | 0.05 ± 0.01 | 5.17 ± 0.08 | 0.16 ± 0.01 | 6.74 ± 0.29 | 0.03 ± 0.01 | 5.36 ± 0.27 | 0.04 ± 0.02 | 6.80 ± 0.28 | 0.02 ± 0.01 |
UCB35625 | 5.18 ± 0.56 | 0.04 ± 0.01 | 5.29 ± 0.38 | 0.05 ± 0.01 | ND | ND | 5.87 ± 0.22 | 0.05 ± 0.01 | 5.87 ± 0.22 | 0.04 ± 0.02 | ND | ND |