TABLE 2.

Signaling parameters of J113863 and UCB35625

Functional parameters were measured on cells expressing CCR2 or CCR5. The pEC₅₀ and Emax values were obtained from experiments as displayed in Figs. 5 and 6. Values represent the mean ± S.E. of at least three independent experiments. NT, not tested; ND, not determined.

Ligands	CCR2						CCR5
	Gαi2		Gαoa		β-Arr2		Gαi2		Gαoa		β-Arr2
	pEC50	Emax	pEC50	Emax	pEC50	Emax	pEC50	Emax	pEC50	Emax	pEC50	Emax
CCL2	8.45 ± 0.13	0.17 ± 0.01	8.61 ± 0.22	0.05 ± 0.01	8.50 ± 0.06	0.14 ± 0.06	NT	NT	NT	NT	NT	NT
CCL4	NT	NT	NT	NT	NT	NT	8.46 ± 0.29	0.08 ± 0.01	8.55 ± 0.20	0.05 ± 0.01	7.85 ± 0.11	0.10 ± 0.04
J113863	5.68 ± 0.27	0.14 ± 0.02	5.17 ± 0.33	0.05 ± 0.01	5.17 ± 0.08	0.16 ± 0.01	6.74 ± 0.29	0.03 ± 0.01	5.36 ± 0.27	0.04 ± 0.02	6.80 ± 0.28	0.02 ± 0.01
UCB35625	5.18 ± 0.56	0.04 ± 0.01	5.29 ± 0.38	0.05 ± 0.01	ND	ND	5.87 ± 0.22	0.05 ± 0.01	5.87 ± 0.22	0.04 ± 0.02	ND	ND