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. 2017 Jan 18;7:39276. doi: 10.1038/srep39276

Figure 2. Network and Pathways of Cardiomyopathy Regulated Genes.

Figure 2

(A) Network of Common Cardiomyopathy regulated genes. Genes commonly upregulated or down-regulated in multiple cardiomyopathy datasets, including RCM, are shown. Genes were connected via protein-protein, pathway, or ChIP-Chip interactions from the NetPerspective algorithm in AltAnalyze. Genes connected by the shortest path among the 14 commonly regulated genes (bold text) are shown, with those up-regulated in RCM vs. non-failing hearts in red and those down-regulated in blue. (B) Oncostatin M (OSM) pathway, highlighting the downstream regulation of the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, with the pathway components up-regulated in RCM vs. non-failing hearts in red and those down-regulated in blue. (C) Transforming growth factor beta (TGFβ) signaling pathway highlighting activation of tumor necrosis factor-alpha (TNF), with the pathway components up-regulated in RCM vs. non-failing hearts in red and those down-regulated in blue.