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. 2017 Jan 16;8:14016. doi: 10.1038/ncomms14016

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Linc-RAM is transcriptionally upregulated by MyoD and directly binds to MyoD in muscle cells. In differentiating cells, Linc-RAM facilitates the recruitment of the SWI/SNF core to myogenic gene promoters through interaction with MyoD, thereby promoting chromatin remodelling and assembly of the transcriptome for transcriptional initiation of myogenic differentiation genes.