Table 1.

Association of rs6904596 at 6p22.1 with both lung cancer risk and blood triglyceride levels

Study	Lung cancer cases/ controls	OR (95% CI)	P*	Study	Triglyceride individuals	$\mathit{\beta }$ (95% CI)	P*
TRICL	12160/16838	1.15 (1.08 to 1.21)	5.50 x 10-6	GLGC	188577	0.0244 (0.013 to 0.035)	1.39 x 10-5
Replication	6097/204657	1.16 (1.07 to 1.25)	2.40 x 10-4	Replication	71113	0.0290 (0.006 to 0.051)	1.14 x 10-2
deCODE	3865/196658	1.17 (1.06 to 1.30)	3.05 x 10-3	deCODE	66027	0.0200 (-0.004 to 0.044)	.10
Harvard	984/ 970	1.18 (0.93 to 1.50)	.17	Holland	5086	0.0891 (0.027 to 0.151)	5.12 x 10-3
Holland	687/ 5158	1.15 (0.96 to 1.37)	.12
Spain	561/ 1871	1.10 (0.88 to 1.37)	.40	Combined	259690	0.0253 (0.015 to 0.035)	1.34 x 10-6
Combined	18257/ 221495	1.15 (1.10 to 1.21)	5.20 x 10-9
PQ-heterogeneity†			.91				.23

*P values were derived from a two-sided Wald test. The reference group for the odds ratio in the lung cancer study was healthy controls without lung cancer. CI = confidence interval; OR = odds ratio.

†Heterogeneity of effect size across studies was evaluated using the Cochran’s Q statistic. The test is defined as one-sided.