Figure 2.

Graphical representation of the hazard ratio estimated in a composite endpoint analysis, denoted HR_C, under various hypothetical scenarios for the true values of the hazard ratio for progression (HR₁), the hazard ratio for death (HR₂), and θ from the illness-death model. In all cases, data were simulated to replicate the general structure of the progression-death data from the N9741 trial. In (A-C), the 60-month rate of death prior to progression was approximately 6%; in (D-F), the hazard was modified to increase this 60-month rate to approximately 35%.