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. 2016 Jul 6;108(11):djw153. doi: 10.1093/jnci/djw153

Table 1.

Details of the studies and participants included*

Study No.
Mean (SD) age at sample collection, y
Median (IQR) selenium concentration (nmol/L for blood; ppm for nails)
Case patients Control subjects Case patients Control subjects Case patients Control subjects
Blood selenium
BLSA (8) 55 55 69.1 (8.6) 68.8 (7.7) 1431 (1317–1671) 1532 (1418–1684)
CARET (13) 235 456 61.5 (6.1) 61.3 (6.2) 1462 (1280–1599) 1425 (1282–1595)
EPIC (17) 959 1,059 59.9 (5.8) 59.6 (5.8) 898 (791–1022) 910 (809–1027)
EPIC-Heidel (19) 148 291 57.4 (5.1) 57.8 (5.1) 1100 (1010–1230) 1100 (994–1210)
FMC (15) 51 92 65.5 (7.7) 65.4 (7.4) 709 (582–912) 734 (595–893)
MEC (18) 461 920 69.0 (7.0) 68.8 (7.1) 1708 (1582–1865) 1718 (1594–1871)
NPC (2) 41 123 66.9 (5.0) 66.8 (4.9) 1433 (1256–1570) 1433 (1241–1605)
PCPT (unpublished) 960 960 63.4 (5.5) 63.3 (5.6) 1687 (1544–1845) 1660 (1529–1830)
PHS (10) 794 794 59.0 (8.2) 58.8 (8.1) 1374 (1221–1532) 1371 (1223–1545)
PLCO (16) 723 879 65.1 (4.8) 64.8 (4.7) 1775 (1589–1946) 1797 (1605–2000)
SU.VI.MAX (unpublished) 100 392 55.1 (4.6) 55.0 (4.6) 1115 (1026–1252) 1127 (995–1254)
Nail selenium
CLUE II (14) 117 233 65.9 (7.5) 65.9 (7.5) 0.77 (0.68–0.86) 0.79 (0.70–0.87)
HPFS (11) 181 181 63.2 (6.4) 63.1 (6.4) 0.79 (0.70–0.91) 0.80 (0.73–0.94)
NLCS (12, 49) 1268 1268 62.7 (4.1) 62.7 (4.1) 0.51 (0.46–0.57) 0.54 (0.48–0.60)
SELECT (4) 404 404 63.3 (6.0) 62.7 (4.1) 0.87 (0.79–0.97) 0.88 (0.77–0.99)
*

The numbers of case patients and control subjects are the number for whom selenium measurements were available. BLSA = Baltimore Longitudinal Study of Aging; CARET = the beta-Carotene and Retinol Efficacy Trial; CLUE II = Campaign against Cancer and Stroke (“Give us a Clue to Cancer”) Study; EPIC = European Prospective Investigation into Cancer and Nutrition; EPIC-Heidel = EPIC-Heidelberg; FMC = Finnish Mobile Clinic Health Examination Survey; HPFS = Health Professionals Follow-up Study; MEC = Multiethnic Cohort; NLCS = Netherlands Cohort Study; NPC = Nutritional Prevention of Cancer Trial; PCPT = Prostate Cancer Prevention Trial; PHS = Physicians’ Health Study; PLCO = Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; SELECT = Selenium and Vitamin E Cancer Prevention Trial; SU.VI.MAX = SUpplémentation en VItamines et Minéraux Anti-oXydants Trial.