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Dependence of desensitization on GnRH concentration and pulse frequency. Panels A, B, and C show model LH outputs in response to 5 minutes pulses of GnRH at pulse periods of 15 (Panel A), 30 (Panel B), and 60(Panel C) minutes. Each panel shows responses to 10 nM(*), 1 nM(+), and O.1 nM(○) GnRH.
