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. 2017 Jan 18;19:7. doi: 10.1186/s13075-016-1206-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Discontinuation of treatment due to any reason. b Discontinuation of treatment due to adverse events. Cumulative treatment discontinuation rates are compared using the log-rank test among groups. Numbers of patients at risk of each group at weeks 0, 4, 8, 12, 16, and 20 are shown. SS the single-strength dosage group, HS the half-strength dosage group, ES the escalation dosage group, LL lower limit, UL upper limit