Table 1.
Effect of miR-34a reconstitution on DMPM cell tumorigenicity following s.c. injection in SCID mice
| Model | miRNA | Engrafted tumors/total micea | Tumor onsetb | TV (mm3) | TVI %c (day) | p valued |
|---|---|---|---|---|---|---|
| STO | Neg | 6/6 | 1 | 440 ± 94 | ||
| miR-34a | 6/6 | 1 | 188 ± 39 | 57 (10) | 0.0003 | |
| MesoII | Neg | 5/5 | 7 | 201 ± 93 | ||
| miR-34a | 5/5 | 12 | 9 ± 12 | 96 (12) | 0.0035 | |
| MP8 | Neg | 5/5 | 18 | 72 ± 35 | ||
| miR-34a | 5/5 | 25 | 1 ± 2 | 98 (21) | 0.0041 |
aNumber of mice presenting s.c. tumors out of number of cell-injected mice
bMedian day of tumor appearance
cTumor volume inhibition % in miRNA34a- over Neg-transfected cell-injected mice
dBy Student’s t test over Neg-transfected cell-injected mice