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In vitro binding of [3H]PDM‐042 to membranes prepared from rat striatum. Saturation binding was determined by incubating [3H]PDM‐042 (0.78–50 nmol/L) with rat striatal membranes for 60 min (A). Specific binding of [3H]PDM‐042 was displaced by PDM‐042 (filled circles) (B) and structurally unrelated PDE10A inhibitor, MP‐10 (filled triangles) (C). Data are expressed as the mean of specific binding in the experiment performed in duplicate.
