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. 2004 Oct 25;101(50):17456–17461. doi: 10.1073/pnas.0407061101

Fig. 1.

Fig. 1.

NaPP1 selectively suppresses BCR-ABL T315A-induced tyrosine phosphorylation and cytokine-independent growth without affecting BCR-ABL WT. (A) Concentrations (1 and 10 μM) of NaPP1 and imatinib mesylate were added to BCR-ABL T315A and BCR-ABL WT expressing BaF3 cells in the presence of 1% WeHI IL-3 containing medium, and total levels of tyrosine phosphorylation and BCR-ABL expression were measured 24 h after inhibitor addition as described (26). Equivalent volumes of DMSO were added to control cells. (B) Concentrations (2 μM) of NaPP1 and imatinib mesylate were added to BCR-ABL T315A and BCR-ABL WT expressing BaF3 cells in the absence of WeHI IL-3 containing medium every 24 h, and cell counts as measured by trypan blue exclusion were obtained 48 h after inhibitor addition. One set of data from a representative experiment repeated three times is shown.