Fig. 2.

BCR-ABL T315A generates a transplantable MPD similar to BCR-ABL WT. (A) Survival curves of mice transplanted with BCR-ABL T315A or BCR-ABL WT cells. Generation of MPD was as described (27). Cell morphology (B) and cell surface expression (C) of CD11b and KIT in leukemic cells from mice transplanted BCR-ABL T315A expressing cells were conducted as described (26–28). Similar patterns of expression were observed for BCR-ABL WT cell populations. Slides were photographed at ×1,000. Cytospins and flourescence-activated cell sorter plots represent an animal from each group, and similar results were obtained in all leukemic mice from each group.