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Summary of the differences between HPV-positive and HPV-negative HNSCC
| HPV-positive | HPV-negative | |
|---|---|---|
| Anatomic site | Tonsil / BOT | All sites |
| Histology | Non-keratinized | Keratinized |
| Age | Younger | Older |
| Gender | 3:1 men | 3:1 men |
| Stage | Tx, T1–2 | Variable |
| Risk factors | Sexual behavior | Alcohol / tobacco |
| Incidence | Increasing | Decreasing |
| Survival | Improved | Unchanging |
BOT: Base of Tongue,
