Skip to main content
. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Behav Brain Res. 2016 Nov 24;320:302–315. doi: 10.1016/j.bbr.2016.11.024

Figure 1.

Figure 1

Schematic illustration of the experimental design for Experiment 1. Each numbered box represents an individual session/day. Following Pavlovian training with a food unconditioned stimulus (US) and lever (CS), rats were classified as STs or GTs and then tested for responses for a novel cue (tone). Next, they were trained to self-administer cocaine (US) in the absence of any explicit cue. During subsequent Pavlovian conditioning sessions (grey), rats received non-contingent tone (CS)-cocaine (US) pairings. Following cocaine self-administration and Pavlovian conditioning, all animals underwent extinction training followed by a cue-induced reinstatement of drug-seeking test. Depending on the experimental stage, an active nose poke produced the cocaine-US (self-administration), no US (extinction), or the CS but no US (reinstatement).