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. 2004 Nov 1;114(9):1272–1280. doi: 10.1172/JCI21022

Figure 5.

Figure 5

Loss of KSR1 increases colon inflammation. IL-10+/–KSR1+/–, IL-10+/–KSR1+/+, or IL-10+/+KSR1+/– mice produced by first-generation crosses of IL-10–/– and KSR1–/–, IL-10–/– and 129/SvEv (KSR1+/+), or BALB/c (IL-10+/+) and KSR1–/– mice, respectively, as well as IL-10–/– (BALB/c) and KSR1–/– (129/SvEv) mice were sacrificed at 8 weeks of age. (A) H&E staining examples of mouse colons (magnification, ×20), and apoptosis detected using an ISOL kit as in Figure 1 are shown (1 representative of each group, 5 mice per group). Arrows represent ISOL-labeled apoptotic nuclei. Histological injury scores appear in Table 1. (B) The number of apoptotic nuclei found per 100 colonic glands is shown (*P < 0.001 compared with IL-10+/–KSR1+/– group).