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. 2016 Sep 28;16(1):61–72. doi: 10.1111/acel.12526

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© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Pooled associations of rs693 and rs562338 with the risks of MI. Symbols show relative risks (RRs) of MI for each SNP separately (M1, filled symbols) and SNPs additive effects (M2, open symbols). The analyses were not conditioned on lipids (dots) and conditioned on TC (squares), and TC and HDL‐C (diamonds). Vertical lines show 95% confidence intervals. Bars show −log₁₀(P‐value). Dotted line shows cutoff for significance −log₁₀(0.05) = 1.3. Figures show the results pooling (a, e) ARIC and FHS, (b, f) MESA and CHS, (c, g) all studies following GWAS, and (d, h) all studies disregarding the effect directions. Other details are in Table S8 (Supporting information).