Table 2.
The associations of genetic variants with lipids
| Genetic factor, model | ARIC, N = 9585 | FHS, N = 8436 | MESA, N = 2680 | CHS, N = 4208 | Mega‐analysis, N = 24 909 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P‐value | β | SE | P‐value | β | SE | P‐value | β | SE | P‐value | β | SE | P‐value | |
| Total cholesterol (TC) | |||||||||||||||
| rs693, M1 | 0.79 | 0.10 | 4.2E‐15 | 0.74 | 0.11 | 1.1E‐11 | 0.44 | 0.18 | 1.7E‐02 | 0.61 | 0.16 | 1.0E‐04 | 0.72 | 0.06 | 7.7E‐30 |
| rs562338, M1 | −1.16 | 0.13 | 2.5E‐18 | −1.05 | 0.14 | 1.4E‐14 | −0.81 | 0.22 | 3.0E‐04 | −1.18 | 0.20 | 3.3E‐09 | −1.08 | 0.08 | 9.8E‐42 |
| rs693, M2 | 0.58 | 0.11 | 4.0E‐08 | 0.50 | 0.12 | 2.0E‐05 | 0.25 | 0.19 | 2.0E‐01 | 0.34 | 0.17 | 4.2E‐02 | 0.49 | 0.07 | 2.6E‐13 |
| rs562338, M2 | −0.92 | 0.14 | 2.2E‐11 | −0.81 | 0.15 | 2.3E‐08 | −0.71 | 0.24 | 2.7E‐03 | −1.04 | 0.21 | 9.8E‐07 | −0.88 | 0.09 | 3.1E‐25 |
| PS‐AA | 0.11 | 0.10 | 2.3E‐01 | 0.06 | 0.11 | 5.6E‐01 | −0.09 | 0.17 | 6.2E‐01 | −0.11 | 0.15 | 4.7E‐01 | 0.04 | 0.06 | 4.8E‐01 |
| PS‐GA | −0.74 | 0.07 | 4.0E‐24 | −0.69 | 0.08 | 2.1E‐18 | −0.45 | 0.13 | 5.8E‐04 | −0.68 | 0.11 | 2.1E‐09 | −0.69 | 0.05 | 2.8E‐51 |
| High‐density lipoprotein cholesterol (HDL‐C) | |||||||||||||||
| rs693, M1 | −0.32 | 0.17 | 5.6E‐2 | −0.41 | 0.17 | 1.5E‐2 | −0.04 | 0.29 | 8.9E‐1 | 0.16 | 0.23 | 5.0E‐1 | −0.24 | 0.10 | 1.5E‐02 |
| rs562338, M1 | 0.04 | 0.22 | 8.4E‐1 | −0.16 | 0.21 | 4.5E‐1 | −0.19 | 0.36 | 5.9E‐1 | 0.10 | 0.29 | 7.5E‐1 | −0.04 | 0.13 | 7.8E‐01 |
| rs693, M2 | −0.34 | 0.18 | 5.3E‐2 | −0.52 | 0.18 | 3.5E‐3 | −0.10 | 0.31 | 7.4E‐1 | 0.20 | 0.21 | 3.2E‐1 | −0.28 | 0.10 | 7.4E‐03 |
| rs562338, M2 | −0.09 | 0.23 | 7.0E‐1 | −0.39 | 0.22 | 7.6E‐2 | −0.23 | 0.38 | 5.4E‐1 | 0.18 | 0.31 | 5.6E‐1 | −0.15 | 0.13 | 2.5E‐01 |
| PS‐AA | −0.27 | 0.16 | 9.3E‐2 | −0.48 | 0.17 | 2.9E‐3 | −0.14 | 0.28 | 6.0E‐1 | 0.18 | 0.22 | 4.1E‐1 | −0.24 | 0.10 | 1.0E‐02 |
| PS‐GA | 0.19 | 0.12 | 1.3E‐1 | 0.20 | 0.12 | 1.0E‐1 | −0.03 | 0.21 | 8.9E‐1 | −0.03 | 0.17 | 8.4E‐1 | 0.13 | 0.07 | 6.2E‐02 |
N denotes maximal number of individuals in the analyses with missing information on rs693, rs562338, TC, and HDL‐C excluded.
M1 denotes model 1 with one reference SNP included.
M2 denotes model 2 with both reference SNPs included.
PS‐AA and PS‐GA denote polygenic scores constructed as counts of the rs693_A or rs562338_A and rs693_G or rs562338_A alleles, respectively.
The effect size beta evaluated for 100 × log10(TC) and 100 × log10(HDL‐C) is the estimate of cumulative genetic effects over multiple examinations using mixed‐effects regression model. Sign of beta indicates direction of the effect in additive genetic models. The effect alleles were as follows: (i) allele(s) A in each SNP and in polygenic score PS‐AA and (ii) alleles G and A in polygenic score PS‐GA.
SE denotes standard error.