Table 3.
The associations of rs693 and rs562338 with risks of myocardial infarction
| Genetic factor, model | ARIC N T/C=9562/764 | FHSa N T/C = 4485/587 | MESA N T/C = 2505/75 | CHS N T/C = 4196/931 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P‐value | β | SE | P‐value | β | SE | P‐value | β | SE | P‐value | |
| Not adjusted for lipids | ||||||||||||
| rs693, M1 | −0.08 | 0.05 | 1.3E‐1 | −0.18 | 0.06 | 1.8E‐3 | 0.19 | 0.17 | 2.5E‐1 | 0.13 | 0.05 | 6.9E‐3 |
| rs562338, M1 | −0.09 | 0.07 | 2.2E‐1 | 0.04 | 0.07 | 5.8E‐1 | −0.01 | 0.21 | 9.5E‐1 | −0.02 | 0.06 | 8.0E‐1 |
| rs693, M2 | −0.11 | 0.06 | 4.8E‐2 | −0.19 | 0.06 | 1.7E‐3 | 0.21 | 0.18 | 2.3E‐1 | 0.14 | 0.05 | 5.6E‐3 |
| rs562338, M2 | −0.13 | 0.07 | 7.5E‐2 | −0.04 | 0.08 | 5.8E‐1 | 0.07 | 0.22 | 7.4E‐1 | 0.04 | 0.06 | 5.0E‐1 |
| Adjusted for total cholesterol | ||||||||||||
| rs693, M1 | −0.10 | 0.05 | 5.2E‐2 | −0.23 | 0.06 | 6.1E‐5 | 0.18 | 0.17 | 2.8E‐1 | 0.13 | 0.05 | 7.3E‐3 |
| rs562338, M1 | −0.05 | 0.07 | 4.9E‐1 | 0.10 | 0.07 | 1.8E‐1 | −1E‐6 | 0.21 | 1.0E‐0 | −0.01 | 0.06 | 8.2E‐1 |
| rs693, M2 | −0.12 | 0.06 | 2.4E‐2 | −0.23 | 0.06 | 1.5E‐4 | 0.20 | 0.17 | 2.6E‐1 | 0.14 | 0.05 | 5.9E‐3 |
| rs562338, M2 | −0.10 | 0.07 | 1.8E‐1 | −0.005 | 0.08 | 9.5E‐1 | 0.08 | 0.22 | 7.1E‐1 | 0.04 | 0.06 | 4.9E‐1 |
| Adjusted for total and high‐density lipoprotein cholesterols | ||||||||||||
| rs693, M1 | −0.12 | 0.05 | 2.4E‐2 | −0.24 | 0.06 | 3.6E‐5 | 0.16 | 0.17 | 3.4E‐1 | 0.13 | 0.05 | 7.7E‐3 |
| rs562338, M1 | −0.05 | 0.07 | 4.5E‐1 | 0.10 | 0.07 | 1.8E‐1 | 0.02 | 0.21 | 9.3E‐1 | 0.001 | 0.06 | 9.8E‐1 |
| rs693, M2 | −0.15 | 0.06 | 8.9E‐3 | −0.24 | 0.06 | 8.7E‐5 | 0.19 | 0.18 | 3.0E‐1 | 0.14 | 0.05 | 4.6E‐3 |
| rs562338, M2 | −0.11 | 0.07 | 1.3E‐1 | −0.007 | 0.08 | 9.2E‐1 | 0.09 | 0.22 | 6.7E‐1 | 0.06 | 0.07 | 3.3E‐1 |
N T/C denotes total number (T) of individuals in the analyses and the number of cases (C) among them.
M1 denotes model 1 with one reference SNP included.
M2 denotes model 2 with both reference SNPs included.
The effect beta was evaluated in the Cox proportional hazard regression model. Sign of beta indicates direction of the effect in additive genetic models with alleles A considered as effect alleles for each SNP.
SE denotes standard error.
a
The 3rd generation cohort of the Framingham Heart Study (FHS) was not included because of small number of MI events (N = 19).