Table 4.
The associations of rs693 and rs562338 with risks of mortality for MI patients
| Genetic factor, model | ARIC, N C = 236 | FHSa, N C = 375 | MESA, N C = 19 | CHS, N C = 637 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P‐value | βa | SE | P‐value | βa | SE | P‐value | βa | SE | P‐value | |
| rs693, M21 | −0.14 | 0.10 | 1.6E‐1 | −0.29 | 0.08 | 1.7E‐4 | 0.43 | 0.36 | 2.3E‐1 | 0.12 | 0.06 | 4.5E‐2 |
| rs562338, M21 | −0.21 | 0.13 | 1.1E‐1 | −0.13 | 0.10 | 2.1E‐1 | 0.71 | 0.40 | 7.1E‐2 | 0.06 | 0.08 | 4.2E‐1 |
| rs693, M22 | −0.14 | 0.10 | 1.6E‐1 | −0.30 | 0.08 | 9.6E‐5 | 0.43 | 0.36 | 2.3E‐1 | 0.13 | 0.06 | 3.0E‐2 |
| rs562338, M22 | −0.22 | 0.13 | 1.0E‐1 | −0.13 | 0.10 | 1.8E‐1 | 0.70 | 0.39 | 7.3E‐2 | 0.07 | 0.08 | 4.0E‐1 |
M21 denotes the model with cases defined as death among MI patients, and the others were considered as controls. The model included both reference SNPs and was adjusted for basic covariates, TC, and HDL‐C. The total samples were as follows: ARIC, N T = 9562; FHS, N T = 4485; MESA, N T = 2505; CHS, N T = 4196.
M22 was the same as M21 except the controls were individuals with no MI. The total samples were as follows: ARIC, N T = 9034; FHS, N T = 4273; MESA, N T = 24494; CHS, N T = 3902.
The number of cases (N C) in the analyses is given in the table.
The 3rd generation cohort of the Framingham Heart Study (FHS) was not included because of small number of deaths after MI events (N = 5).