Table 1.
Age, body and tissue mass, blood pressure and blood glucose, plasma insulin, and homeostatic model assessment of beta‐cell function (HOMA‐B) and insulin resistance (HOMA‐IR) in untreated and rapamycin‐treated young and old mice
| Young | Old | Young Rap | Old Rap | N's | |
|---|---|---|---|---|---|
| Age (months) | 3.8 ± 0.6 | 30.3 ± 0.2a | 4.0 ± 0.0 | 30.3 ± 0.2a | 9–15 |
| Body mass (g) | 32.5 ± 1.6 | 35.6 ± 1.4 | 29.3 ± 0.4 | 36.9 ± 1.3a | 8–15 |
| Gastrocnemius mass (mg) | 243 ± 23 | 150 ± 8a | 170 ± 2a | 139 ± 5a | 7–12 |
| Heart mass (mg) | 157 ± 10 | 202 ± 7a | 134 ± 4a | 209 ± 6a | 7–12 |
| Liver mass (g) | 1.61 ± 0.06 | 1.97 ± 0.07a | 1.21 ± 0.04a | 1.87 ± 0.08a | 7–12 |
| Spleen mass (mg) | 82 ± 5 | 75 ± 13a | 64 ± 2a | 116 ± 21a , b | 6–8 |
| Epididymal WAT mass (mg) | 679 ± 99 | 327 ± 73 | 456 ± 23 | 576 ± 102 | 7–12 |
| Mean arterial pressure (mmHg) | 109 ± 3 | 101 ± 5 | 101 ± 4 | 95 ± 3 | 7–8 |
| AUCglc (%fasted) | 11210 ± 365 | 12410 ± 388a | 14620 ± 1127a | 11241 ± 333b | 8–12 |
| Fed blood glucose (mg dL−1) | 142 ± 3 | 125 ± 6a | 134 ± 3 | 115 ± 5a | 8–13 |
| Fed plasma insulin (μU mL−1) | 23.8 ± 4.3 | 47.3 ± 7.7a | 30.8 ± 2.9 | 39.0 ± 5.1 | 7–10 |
| HOMA‐IR (%) | 4.4 ± 0.5 | 5.5 ± 0.6 | 4.2 ± 0.4 | 5.1 ± 0.7 | 7–10 |
| HOMA‐B (%) | 110.8 ± 10.9 | 175.5 ± 20.4a | 117.5 ± 8.4 | 180.6 ± 7.9a | 7–10 |
Rap, rapamycin treated, WAT, white adipose tissue.
N = 6–15/group.
Data are means ± SEM, P < 0.05.
a
Denotes difference from young.
b
Denotes difference from untreated old.