Representative 68Ga-BBN PET/CT images (left), MR images (middle), and immunohistochemically stained tissue samples (right) of patients with gliomas of different grades. (A) A 5-y-old girl with space-occupying lesion in cerebellar lobe diagnosed as pilocytic astrocytoma, WHO grade I. Lesion had SUVmax of 2.35 and SUVmean of 1.31, showed enhancement on T1-weighted MRI, and stained positively for GRPR. (B) A 4-y-old girl with multiple space-occupying lesions diagnosed as WHO grade II astrocytoma. Lesions had SUVmax of 2.05 and SUVmean of 1.45, were identified by contrast-enhanced T1-weighted MRI, and stained positively for GRPR. (C) A 14-y-old boy with space-occupying lesion in thalamic connections of temporal lobe diagnosed as WHO grade III anaplastic oligoastrocytoma. Lesion had SUVmax of 1.98 and SUVmean of 1.08, showed enhancement on T1-weighted MRI, and stained positively for GRPR. (D) A 44-y-old man with space-occupying lesion in left temporal lobe diagnosed as WHO grade IV glioblastoma multiforme. Lesion had SUVmax of 1.95 and SUVmean of 0.98, showed enhancement on T2-weighted MRI, and stained positively for GRPR.