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. 2016 Winter;15(Suppl):19–27.

Table 3.

Anti- HIV activity of terpenoid compounds from E. erythradenia

Compound Anti HIV activity Cytotoxicity Therapeutic index
IC50 (μM)a CC50 (μM)b TI (CC50/IC50)
1a & 1b 0.003 0.014 4.67
2 0.006 0.022 3.67
3 0.002 0.011 5.5
4 0.009 0.022 2.44
5 0.036 0.004 0.11
6 0.007 0.084 11.75
7 0.008 3.264 380.64
8 0.044 0.168 26.68
Nevirapine < 0.064 6.74 > 105.31
a

IC50 = Concentration causing 50% HIV activity inhibition.

b

CC50 = Concentration causing 50% cellular cytotoxicity.