Table 3.
Compound | Anti HIV activity | Cytotoxicity | Therapeutic index |
---|---|---|---|
IC50 (μM)a | CC50 (μM)b | TI (CC50/IC50) | |
1a & 1b | 0.003 | 0.014 | 4.67 |
2 | 0.006 | 0.022 | 3.67 |
3 | 0.002 | 0.011 | 5.5 |
4 | 0.009 | 0.022 | 2.44 |
5 | 0.036 | 0.004 | 0.11 |
6 | 0.007 | 0.084 | 11.75 |
7 | 0.008 | 3.264 | 380.64 |
8 | 0.044 | 0.168 | 26.68 |
Nevirapine | < 0.064 | 6.74 | > 105.31 |
IC50 = Concentration causing 50% HIV activity inhibition.
CC50 = Concentration causing 50% cellular cytotoxicity.