Table 3.
Effects of amitriptyline (AMT, 5, 10, 20 mg/kg, i.p.) on pathologic parameters of colitis induced by acetic acid in reserpine induced (6 mg/kg, i.p.) depressed rats
| Group |
Inflammation
Severity (0-3) |
Inflammation
Extent (0-3) |
Crypt Damage
(0-4) |
Total Colitis Index (0-10) |
|---|---|---|---|---|
| Sham | 0 (0-0)** | 0 (0-0)** | 0 (0-0)** | 0 (0-0)** |
| Control | 3 (2-3) | 3 (2-3) | 4 (1-4) | 9.5 (6-10) |
| Dex.1 | 0.5(0-1)** | 0 (0-2)** | 0 (0-2)** | 1 (0-5)** |
| RSP | 3 (1-3) | 3 (1-3) | 4 (1-4) | 10 (4-10) |
| AMT 5 | 2.5 (1-3) | 2.5 (1-3) | 1.5 (0-4) | 6.5 (2-10) |
| AMT 10 | 1 (1-1)** | 1 (0-2)** | 0(0-0)** | 2 (1-3)** |
| AMT 20 | 0.5 (0-3)* | 0.5 (0-3)* | 0 (0-1)** | 1 (0-7)** |
Dex. 1=dexamethasone (1mg/kg), RSP= reserpine (6mg/kg), i.p. =intraperitoneally; Values are presented as median (range) of six rats in each group;
*
P< 0.05,
**
P<0.01 compared to control, Kruskal–Wallis followed by Mann-Whitney U test.