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. Author manuscript; available in PMC: 2017 Jan 18.
Published in final edited form as: Sci Signal. 2016 Sep 6;9(444):ra87. doi: 10.1126/scisignal.aaf0890

Fig. 7. Model for MuSK regulation of BMP4 signaling.

Fig. 7

MuSK binds to BMPs and the BMP receptors ALK3 and ALK6 and regulates the transcriptional output of BMP signaling in muscle cells. MuSK regulation of BMP signaling is cell type-specific because BMP induced the expression of different sets of genes in myoblasts and myotubes in a manner that depended on MuSK. The kinase activity of MuSK, which is required for proper NMJ formation, is dispensable for MuSK-mediated regulation of BMP signaling. JM, juxta-membrane; TK, tyrosine kinase; CRD/Fz, CRD/frizzled-like domain.