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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Semin Hematol. 2016 Nov 18;54(1):12–18. doi: 10.1053/j.seminhematol.2016.11.001

Figure 1.

Figure 1

Accumulation of various forms of DNA damage in the aged HSC compartment is present throughout aging of the HSC compartment, with certain combinations driving clonal expansion. The selection advantage conferred by mutations in these clones may also contribute to the progression towards hematopoietic malignancies.