Figure 1.

A, B, Integrated taste responses from the CT nerve in a control (Control) mouse to a concentration series of NaCl and to 0.5 m NH₄Cl before lingual application of the epithelial channel blocker amiloride (A) and with amiloride (B). C, D, Integrated taste responses from the CT in an αENaC knock-out (KO) mouse to a concentration series of NaCl and to 0.5 m NH₄Cl before lingual application of amiloride (C) and with amiloride (D). E, Mean (±SEM) relative taste responses to a concentration series of NaCl from the CT in control and αENaC KO mice before (solid lines) and with lingual application of amiloride (dotted lines). F, G, Integrated taste responses from the GSP in a Control mouse to a concentration series of NaCl and to 0.5 m NH₄Cl before lingual application of amiloride (F) and with amiloride (G). H, I, Integrated taste responses from the GSP nerve in an αENaC KO mouse to a concentration series of NaCl and to 0.5 m NH₄Cl before lingual application of amiloride (H) and with amiloride (I). The record in I is broken to enable registration of responses with G. Only spontaneous activity was not shown in I. J, Relative taste responses to a concentration of NaCl from the GSP in the same control mouse in which F and G were recorded and in the same αENaC KO mouse in which H and I were recorded before (solid lines) and with lingual application of amiloride (dotted lines). *p < 0.05 in the group-related comparisons in E.