Table 1.
Calculation of sCr RCV for different baseline values hypothesising optimal analytical variation (CVA=0.5CVI) and 95% significance level.*
| sCr at baseline (in mg/dL) | sCr at baseline (in μmol/L) | RCV(%) | Absolute changes needed to be significant (in mg/dL) | Absolute changes needed to be significant (in µmol/L) | Limit for a significant change (in mg/dL) | Limit for a significant change (in µmol/L) | KDIGO criterion in mg/dL | KDIGO criterion in µmol/L | % from baseline |
|---|---|---|---|---|---|---|---|---|---|
| 0.75 | 66.30 | 18.28 | 0.10 | 8.84 | 0.85 | 75.14 | 0.30 | 26.52 | 40.00 |
| 1.00 | 88.40 | 18.28 | 0.18 | 15.91 | 1.18 | 104.31 | 0.30 | 26.52 | 30.00 |
| 1.50 | 132.60 | 18.28 | 0.27 | 23.86 | 1.92 | 169.72 | 0.30 | 26.52 | 20.00 |
| 2.00 | 176.80 | 18.28 | 0.37 | 32.70 | 2.74 | 242.21 | 0.30 | 26.52 | 15.00 |
| 2.50 | 221.0 | 18.28 | 0.46 | 40.66 | 3.65 | 322.66 | 0.30 | 26.52 | 12.00 |
| 3.00 | 265.20 | 18.28 | 0.55 | 48.62 | 4.66 | 411.94 | 0.30 | 26.52 | 10.00 |
| 3.50 | 309.40 | 18.28 | 0.65 | 57.46 | 5.76 | 509.18 | 0.30 | 26.52 | 8.57 |
| 4.00 | 353.60 | 18.28 | 0.75 | 66.30 | 6.95 | 614.38 | 0.30 | 26.52 | 7.50 |
*
CVI is taken from current Ricos database and represents CVI in health. Calculation of RCV shows that different absolute values are needed for a significant change according to baseline. On the other hand the fixed 0.30 mg/dL (26.5 μmol/L) of the AKI definition gives false negative results when baseline sCr is < 2.00mg/dL (176.8 μmol/L) and false positive results when baseline sCr is > 2.00 mg/dL (176.8 μmol/L)