Table 2. Enrichment analysis using Set Distiller analysis from GeneDecks (version 3) showing descriptors/pathways and the number of genes modulated for immune, compound and cellular related pathways.
Enrichment analysis of pathways are statistically significant with a p-value <0.05 (Bonferroni corrected).
| GeneDecks Set Distiller Analysis | Attribute Type | poly(I:C) | Lh-R0052 | Bb-R0071 | Bl-R0033 | Lh-R0052-SLP | PC | PC | Lh-R0052-SLP |
|---|---|---|---|---|---|---|---|---|---|
| only | poly(I:C) | poly(I:C) | poly(I:C) | poly (I:C) | poly(I:C) | only | only | ||
| Immune Related | Number of Genes Modulated | ||||||||
| Immune System Phenotype | PHENOTYPE | 88 | 85 | 77 | 59 | 32 | 22 | - | - |
| TNF Signaling Pathway | KEGG_PATHWAY | 16 | 12 | 14 | - | - | - | - | - |
| MAPK Signaling Pathway | SUPER_PATHWAY | 21 | 16 | 14 | 6 | - | 4 | - | - |
| NF-KappaB Signaling Pathway | KEGG_PATHWAY | 13 | 14 | 12 | 4 | 3 | 7 | - | - |
| NF-KappaB Family Pathway | SUPER_PATHWAY | 17 | 13 | 11 | - | - | 1 | - | - |
| Jak-STAT Signaling Pathway | SUPER_PATHWAY | 7 | 1 | 2 | - | 3 | 1 | - | - |
| Immune response IFN Alpha/Beta Signaling Pathway | SUPER_PATHWAY | 8 | - | - | - | - | - | - | - |
| Cytokine-cytokine Receptor Interaction | KEGG _PATHWAY | 16 | 16 | 12 | 8 | 7 | 7 | - | - |
| Chemokine Signaling | KEGG_PATHWAY | 13 | 14 | 6 | - | 6 | 6 | - | - |
| Toll-like receptor Signaling Pathway | KEGG_PATHWAY | 8 | 12 | 11 | 2 | 2 | 4 | - | - |
| IL-17 Family Signaling Pathways | SUPER_PATHWAY | 9 | 2 | 4 | - | - | - | - | - |
| Immune Response IL-23 Signaling Pathway | SUPER_PATHWAY | 12 | 3 | 5 | - | - | 3 | - | - |
| NOD-like Receptor Signaling Pathway | SUPER_PATHWAY | 16 | 3 | 4 | 2 | 2 | 5 | - | - |
| RIG-I-like Receptor Signaling Pathway | KEGG_PATHWAY | 6 | 4 | 4 | - | - | 4 | - | - |
| Inactivation of MAPK Activity | GO_MOLEC_FUNC | - | 6 | - | - | - | - | - | - |
| BAFF in B-Cell Signaling | SUPER_PATHWAY | 4 | 9 | 8 | - | - | - | - | - |
| Immune Response MIF-mediated Glucocorticoid Regulation | PATHWAY_MLPR | 6 | 6 | 8 | - | - | 3 | - | - |
| Immune Response IL-2 Activation and Signaling Pathway | SUPER_PATHWAY | 7 | 9 | 7 | - | - | - | - | - |
| Compound/Immune Related | |||||||||
| VEGF | COMPOUND | 34 | 41 | 38 | 36 | 12 | 14 | - | - |
| Rantes | COMPOUND | 18 | - | 15 | - | - | 8 | - | - |
| Nitric Oxide | COMPOUND | 33 | 36 | 29 | 29 | - | 11 | - | - |
| H2O2 | COMPOUND | 32 | 11 | 27 | 22 | - | 10 | - | - |
| Progesterone | COMPOUND | 33 | 10 | - | 25 | 14 | 8 | - | - |
| Superoxide | COMPOUND | 18 | - | - | 20 | 3 | 6 | - | - |
| Histamine | COMPOUND | 13 | - | - | 16 | - | - | - | - |
| Cellular/Signaling Related | |||||||||
| Homeostasis/Metabolism Phenotype | PHENOTYPE | 107 | 100 | 80 | 74 | 37 | 24 | - | - |
| Signal Transduction | GO_BIOL_PROC | 51 | - | 24 | 30 | - | 13 | - | - |
| PAK Pathway | SUPER_PATHWAY | 37 | - | 19 | - | - | - | - | - |
| Focal Adhesion | PATHWAT_KEGG | 10 | - | 12 | 9 | - | - | - | - |
| Cell Adhesion | GO_BIOL_PROC | 20 | 19 | - | 18 | - | - | - | - |
| p53 Signaling Pathway | SUPER_PATHWAY | 7 | - | 10 | - | - | - | - | - |
| Apoptosis Signaling | SUPER_PATHWAY | 20 | 9 | 6 | - | - | 4 | - | - |
| Integrin Pathway | SUPER_PATHWAY | 15 | 20 | 17 | - | - | - | - | - |
| EGFR1 Signaling Pathway | SUPER_PATHWAY | - | 11 | - | - | - | - | - | - |
| PI3K-Akt signaling Pathway | SUPER_PATHWAY | 12 | 16 | 6 | 10 | 3 | 1 | - | - |