Skip to main content
. 2017 Jan 18;12(1):e0170347. doi: 10.1371/journal.pone.0170347

Fig 5. The DNA damage response was activated in monocytes co-cultured with activated macrophages for 24 h.

Fig 5

(A) Monocytes displayed pATM immunostaining when they were co-cultured with activated macrophages (Mph-PMA), but not with non-activated macrophages (Mph-Solvent). (B) Monocytes showed increased 53BP1 foci formation after co-culture with activated macrophages. (C) There was stabilisation of p53 protein as well as phosphorylation of p53 at position Ser46 and phosphorylation of CHK2 in monocytes exposed to activated macrophages (Mph-PMA).