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. 2017 Jan 18;12(1):e0168556. doi: 10.1371/journal.pone.0168556

Fig 2. Performance at motor-related tasks.

Fig 2

Both male (A) and female (B) HdhQ150 mice performed better on the rotarod compared to controls, but performance of all animals deteriorate with no difference between HdhQ150 and controls beyond 55 weeks of age. HdhQ150 male (C) and females (D) developed a general age-related hypoactivity in an open-field arena. Fore-limb grip strength capactiy was lower in HdhQ150 male mice from as early as 16 weeks of age (E), whereas a deficit in female HdhQ150 was detectable from 53 weeks (F). Similarly, fore- and hind-limb grip strength, taken together, was progressively lower in both male and female HdhQ150s versus WTs (G & H). All data presented as means ± SEM; *p < .05, **p < .01, ***p < .001.