Figures 1.

Subconfluent cultures of T98G cells (Figure 1) or MO59K (Figure 2) were treated with 0.1 nM, 1 nM and 10 nM concentrations of karenitecin for 72 hours and subjected to different doses of irradiation (1 Gy – 8.5 Gy). The control set of cells was treated with the indicated doses of radiation, or karenitecin, or with the vehicle control (DMSO) alone. The cells were harvested and an optimum number of cells were plated and allowed to grow for 14 days. The resulting colonies were stained and counted. Each graphed point represents mean values ± SE values of triplicate dishes (variation less than 5%).