Table 2.
Differences in average monthly atorvastatin and rosuvastatin utilization among coupon users and non-users.*
| Time following incident statin fill | Time
|
||||
|---|---|---|---|---|---|
| 1 month | 1 year | 2 years | 3 years | 4 years | |
| Statin Utilization (Average pill-days dispensed) | |||||
|
| |||||
| No coupons | |||||
| Predicted level, pill-days (SE) | 29.1 (0.0) | 23.7 (0.0) | 24.5 (0.0) | 24.7 (0.0) | 25.4 (−0.1) |
|
| |||||
| Other coupon | |||||
| Predicted level, pill-days (SE) | 28.3 (−0.1) | 23.7 (−1.2) | 24.7 (−2.8) | 24.9 (−4.4) | 25.2 (−6.1) |
| Difference from counterfactual** | −0.7 (−0.1) | 0.1 (−1.2) | 0.2 (−2.8) | 0.2 (−4.4) | −0.1 (−6.1) |
|
| |||||
| Initial statin coupon | |||||
| Predicted level, pill-days (SE) | 28.4 (−0.2) | 23.8 (−3.0) | 24.3 (−6.7) | 24.7 (−10.5) | 24.7 (−14.3) |
| Difference from counterfactual | −0.8 (−0.2) | −0.1 (−3.0) | −0.4 (−6.7) | 0.0 (−10.5) | −0.6 (−14.3) |
|
| |||||
| Subsequent statin coupon | |||||
| Predicted level, pill-days (SE) | 26.7 (−0.1) | 24.0 (−2.1) | 24.5 (−4.6) | 24.8 (−7.2) | 25.1 (−9.9) |
| Difference from counterfactual | −2.2 (−0.1) | 0.3 (−2.1) | −0.2 (−4.6) | 0.0 (−7.2) | −0.4 (−9.9) |
|
| |||||
| Statin Switching (Cumulative probability of switching from one statin to another) | |||||
|
| |||||
| No coupons | |||||
| Predicted level, percent switching (SE) | 1.5 (0.0) | 16.6 (−0.1) | 27.4 (−0.2) | 35.6 (−0.3) | 42.8 (−0.4) |
|
| |||||
| Other coupon | |||||
| Predicted level, percent switching (SE) | 1.9 (−0.1) | 18.9 (−0.4) | 31.5 (−0.7) | 42.3 (−1.0) | 51.4 (−1.2) |
| Difference from counterfactual | 0.3 (−0.1) | 1.9 (−0.5) | 3.6 (−0.7) | 5.9 (−1.0) | 7.7 (−1.3) |
|
| |||||
| Initial statin coupon | |||||
| Predicted level, percent switching (SE) | 1.4 (−0.2) | 14.4 (−0.9) | 25.5 (−1.8) | 36.0 (−3.5) | 45.5 (−5.6) |
| Difference from counterfactual | −0.1 (−0.2) | −1.9 (−1.0) | −1.1 (−1.8) | 1.8 (−3.5) | 4.7 (−5.6) |
|
| |||||
| Subsequent statin coupon | |||||
| Predicted level, percent switching (SE) | 1.4 (−0.2) | 15.6 (−0.8) | 28.3 (−1.1) | 39.3 (−1.4) | 48.8 (−1.6) |
| Difference from counterfactual | −0.2 (−0.2) | −1.4 (−0.8) | 0.6 (−1.1) | 3.4 (−1.4) | 5.6 (−1.7) |
|
| |||||
| Statin Termination (Cumulative Probability of failure to refill for period of at least 6 months) | |||||
|
| |||||
| No coupons | |||||
| Predicted level, percent terminating (SE) | 12.0 (−0.1) | 39.2 (−0.1) | 50.8 (−0.2) | 56.3 (−0.2) | 60.7 (−0.2) |
|
| |||||
| Other coupon | |||||
| Predicted level, percent terminating (SE) | 2.3 (−0.1) | 14.9 (−0.3) | 24.1 (−0.4) | 30.2 (−0.5) | 35.9 (−0.6) |
| Difference from counterfactual | −9.9 (−0.1) | −25.1 (−0.4) | −27.6 (−0.5) | −27.0 (−0.5) | −25.7 (−0.6) |
|
| |||||
| Initial statin coupon | |||||
| Predicted level, percent terminating (SE) | 8.2 (−0.5) | 31.3 (−1.0) | 41.8 (−1.3) | 46.3 (−1.6) | 50.6 (−2.1) |
| Difference from counterfactual | −3.5 (−0.5) | −6.9 (−1.1) | −8.7 (−1.3) | −9.9 (−1.6) | −10.5 (−2.1) |
|
| |||||
| Subsequent statin coupon | |||||
| Predicted level, percent terminating (SE) | 0.4 (−0.1) | 8.3 (−0.5) | 15.1 (−0.6) | 20.7 (−0.8) | 25.9 (−1.0) |
| Difference from counterfactual | −11.6 (−0.1) | −30.6 (−0.5) | −35.2 (−0.7) | −34.9 (−0.8) | −33.9 (−1.0) |
*
Values represent 12-month averages at varying duration of follow-up;
**
Difference from counterfactual represents the difference in average predicted values between coupon users and their counterfactual non-coupon using counterparts within each group (initial, subsequent, non-statin);
Source: IMS Health Lifelink LRx Data, 2007–2013