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Mice were stratified into predicted to live (Live-P) or predicted to die (Die-P) on the basis of plasma levels of IL-6. Mice were treated with the NK-1RA or vehicle by intraperitoneal injection starting 8 hours after the onset of sepsis.
| Group (n) | Treatment started 8 hours post CLP | Pulse distension | IL-6 (ng/ml) | 5 day survival |
|---|---|---|---|---|
| Live-P (11) | NK-1RA | 370 ± 36 | 4 ± 2 | 88% |
| Live-P (9) | Vehicle | 375 ± 37 | 1 ± 0.5 | 85% |
| Die-P (12) | NK-1RA | 258 ± 36 | 35 ± 13 | 38% |
| Die-P (12) | Vehicle | 247 ± 27 | 52 ± 16 | 23% |
