Fig. 2.

Effect of epicatechin on renal function and histology in mouse cisplatin nephropathy at death. The level of serum creatinine (A) and blood urea nitrogen (BUN; B) are shown. Periodic acid-Schiff (PAS) staining demonstrates the representative histological features in the sham group (C), sham group with epicatechin treatment (D), cisplatin group (E), and cisplatin with epicatechin group (F). Quantification of acute tubular necrosis (ATN) score from these groups is shown (G) as well as terminal uridine deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining in the sham group (H), sham with epicatechin group (I), cisplatin group (J), and cisplatin with epicatechin group (K). Blue dot indicates positive cells, while red color indicates nuclear staining. A quantification of TUNEL-positive cells from these groups is also shown (G). Bar = 50 μm.