Fig. 4.

Increased urothelial release of purines occurs during filling of monkey bladders. A: chromatograms of intraluminal fluid collected during low (10 ml) and high (50 ml) distention of isolated Cynomolgus monkey bladders at 10 ml/min infusion rate. The release of purines from the urothelium is increased during bladder filling. Of note, the samples in A were diluted 5× to obtain chromatography signals in scale. B: averaged data (means ± SE) summarizing the bladder filling-evoked release of purines in pmol/g tissue from monkey bladder urothelium. **P < 0.01, significant difference from 10 ml infusion. No. of experiments is in parentheses.