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Effect of PLC-ε deficiency on LPS-induced lung polymorphonuclear leukocyte (PMN) infiltration and injury. Lung homogenates and BAL fluids were collected from WT and KO mice exposed to LPS as in Fig. 1. Lung homogenates were analyzed for tissue myeloperoxidase (MPO) activity (A), and BAL fluids were analyzed for PMN counts (B) and total protein (C). Data are means ± SE (n = 3–5 for each condition). *P <0.05 vs. saline WT; #P vs. LPS WT.
