Table 1.
Intracellular signaling pathways for AQP2 trafficking or endocytosis
| Pathways | Protein Modification of AQP2* | Reference |
|---|---|---|
| Trafficking | ||
| cAMP/PKA | Phosphorylation (S256) | Christensen et al. (17) |
| Katsura et al. (51) | ||
| Intracellular calcium (Ca2+) mobilization (calcium-calmodulin-mediated myosin activation) | Phosphorylation (S256) | Chou et al. (16) |
| PI3K-dependent activation of AKT | Phosphorylation (S256) | Pisitkun et al. (108) |
| AS160 phosphorylation | N.A. | Kim et al. (52) |
| RhoA-dependent cytoskeletal dynamics | Phosphorylation (S256) | Tamma et al. (139) |
| Endocytosis | ||
| Clathrin-mediated endocytosis | Sun et al. (136) | |
| Ubiquitination of AQP2 | Ubiquitination (K270) | Kamsteeg et al. (49) |
| PGE2 | Phosphorylation (S256) | Olesen et al. (103) |
| Phosphorylation (S264) | ||
| Phosphorylation (S269) | Zelenina et al. (159) | |
| Dopamine | Ubiquitination (K270) | Boone et al. (8) |
| Phosphorylation (S261) | Nejsum et al. (94) |
AS160, Akt substrate of 160 kDa; AQP2, aquaporin-2; PGE2, prostaglandin E2; PI3K, phosphatidylinositol-3-kinase.
*
Protein modification of AQP2 is found within the pathway.