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. 2004 Sep 23;23(20):4061–4071. doi: 10.1038/sj.emboj.7600402

Figure 4.

Figure 4

SUZ12 KO embryos are compromised in proliferation. (A) Different magnifications of IHC staining of BrdU in WT (top panels) and KO (bottom panels) 7.5 dpc embryos. The mice were injected with BrdU (150 mg/kg) for 60 min before they were killed. (B) Average of the percentage of BrdU-positive cells in both WT and KO embryos. The standard deviation (s.d.) of the mean is indicated. A total of 1086 cells in WT embryos and 936 cells in KO embryos were counted. (C) Different magnifications of IHC staining of phosphorylation of Ser10 of histone H3 in WT (top panels) and KO (bottom panels) 7.5 dpc embryos. (D) Average of the percentage of H3 Ser10 phosphorylated cells in both WT and KO embryos. s.d. is indicated. A total of 501 cells in WT embryos and 309 cells in KO embryos were counted. (E) Different magnifications of TUNEL staining in WT (top panels) and KO (bottom panels) 7.5 dpc embryos.