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. 2004 Sep 30;23(20):4096–4105. doi: 10.1038/sj.emboj.7600415

Figure 5.

Figure 5

Characterization of Tg mAPP/RAGE and Tg mAPP/DN-RAGE mice: effect on AChE activity. (A1, A2) AChE activity was determined histochemically in the subiculum of mice of the indicated genotype at 3–4 (A1; n=4–9/group) and 14–18 months (A2; n=5–12/group) of age: nonTg littermate (nonTg), Tg RAGE (RAGE), Tg mAPP (mAPP), and Tg mAPP/RAGE (mAPP/RAGE). The bar graph shows the results of image analysis. (B) Representative images from AChE histochemical staining from the subiculum of mice of the indicated genotype from the experiment in A1. Scale bar=10 μm. (C1, C2) AChE activity was determined as above in the indicated mice (nonTg, Tg DN-RAGE (DN-RAGE), Tg mAPP (mAPP), and Tg mAPP/DN-RAGE (mAPP/DN-RAGE)) at 3–4 months (C1; n=7–12/group) and 14–18 months of age (C2; n=7–12/group). (D) Representative images of AChE staining for the indicated mice from the experiment in C2. Scale bar=10 μm. (E) Area occupied by synaptophysin immunoreactivity in the stratum lacunosum moleculare of the hippocampus in mice of the indicated genotype at 3–4 months of age (mean±s.e. are shown).